Ceritinib 150 mg – Targeted Therapy for ALK-Positive Lung Cancer
What is Ceritinib 150 mg?
Ceritinib 150 mg is a targeted anti-cancer medication used for the treatment of non-small cell lung cancer (NSCLC) that is ALK-positive (anaplastic lymphoma kinase positive). Classified as an ALK inhibitor, it works by blocking the abnormal proteins that drive the growth of cancer cells in certain lung cancer patients.
It is a life-saving therapy intended for patients whose tumors have a specific ALK gene rearrangement. it is especially beneficial for patients who cannot tolerate or no longer respond to previous ALK-targeted therapies like crizotinib.
Who Should Use Ceritinib?
This is specifically indicated for:
- Adults with ALK-positive metastatic NSCLC
- Patients who have progressed or are intolerant to crizotinib
- Patients with brain metastases or CNS involvement
Its use is based on the results of molecular testing that confirms ALK positivity.
How Ceritinib 150 mg Works
it inhibits the abnormal ALK fusion protein responsible for cancer cell survival and proliferation in a subset of NSCLC patients. By targeting ALK, it prevents the cancer from growing and spreading further.
Key therapeutic actions of Ceritinib include:
- Suppressing tumor progression
- Reducing cancer cell viability
- Delaying metastasis, including to the brain
- Improving progression-free survival
As a targeted therapy, it is designed to attack only cancerous cells that carry the ALK mutation, minimizing damage to healthy tissue and reducing chemotherapy-like side effects.
Key Benefits of Ceritinib 150 mg
🧬 Precision Targeting
it precisely targets cancer cells with ALK mutations, offering a tailored treatment for NSCLC.
💊 Oral Convenience
Taken as a once-daily oral tablet, it eliminates the need for frequent hospital visits for infusions.
🧠 Effective Against Brain Metastases
Ceritinib has central nervous system (CNS) activity, making it effective for patients with cancer spread to the brain.
🩺 Improved Outcomes in ALK-Positive NSCLC
Studies show higher response rates and prolonged disease control in patients with it compared to older therapies.
Recommended Dosage & Administration
- Standard Dose: 750 mg once daily on an empty stomach
- (Usually taken as 5 tablets of Ceritinib 150 mg)
- With food: Newer guidelines may allow 450 mg with food, but only under doctor’s advice
Always take as prescribed by your oncologist. Do not chew or break the tablet. Swallow whole with water.
Common Side Effects
Like most anti-cancer medications, it may cause some side effects, including:
- Nausea and vomiting
- Diarrhea or abdominal pain
- Fatigue
- Elevated liver enzymes
- Vision changes
- Cough or breathing issues
Serious risks may include:
- Liver toxicity
- QT prolongation (heart rhythm changes)
- Pancreatitis
- Pneumonitis
Regular monitoring and dose adjustment may be required to manage side effects.
Precautions Before Use
- Conduct ALK mutation testing before initiation
- Not recommended during pregnancy or breastfeeding
- Inform your doctor of existing heart, liver, or gastrointestinal conditions
- Avoid grapefruit and grapefruit juice during therapy
- Regular ECG and liver function monitoring is essential
Storage Instructions
- Store below 30°C (86°F)
- Keep in the original blister pack to protect from moisture
- Keep out of reach of children
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FAQs
❓ Is it chemotherapy?
No. it is a targeted therapy—specifically, an ALK inhibitor—used for lung cancers with ALK gene mutations.
❓ Can it be used as first-line treatment?
Yes. It can be prescribed either as a first-line treatment or after resistance to other ALK inhibitors.
❓ Does it work for brain metastases?
Yes. it has shown effectiveness against central nervous system (CNS) lesions, including brain metastases in ALK-positive patients.
Final Thoughts
Ceritinib 150 mg is a powerful, precision-targeted therapy that offers hope to patients with ALK-positive non-small cell lung cancer. With its proven efficacy and oral convenience, it helps patients maintain better quality of life during treatment.
Whether you’re newly diagnosed or have progressed on prior therapy, It may offer renewed control over cancer progression.
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